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Methoxy PEG Succinimidyl Carboxymethyl Ester

产品代号:

M-PEG-SCM

产品纯度:

≥ 95%

包装规格:

1g, 10g, 100g等(特殊包装需收取分装费用)

分子量:

1000 Da-40000 Da,等

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科研客户小批量一键采购地址(小于5克)

  • 产品描述
  • 参考文献
  •   甲氧基乙酯可以与药物或其他分子中的氨基进行反应,甲氧基聚乙二醇羧甲基琥珀酰亚胺酯中聚乙二醇连与NHS活性酯之间是通过醚键连接的,醚键是一种稳定的不可降解的化学键。在室温下PH=7-8的环境中本品可以快速与赖氨酸等分子中的氨基反应。

      本品甲氧基聚乙二醇琥珀酰亚胺羧甲基酯的水解半衰期非常短,所以更能有效地选择具有空间结构优势的氨基基团进行聚乙二醇化。

      键凯科技提供M-SCM分子量的1000 Da,2000 Da,5000 Da,10000 Da,2000 Da,30000 Da,35000 Da,40000 Da 的产品1克和10克包装。

      键凯科技提供分装服务,需要收取分装费用,如果您需要分装为其他规格请与我们联系。

      键凯科技同时提供其他分子量的M-SCM产品,如你需要请与我司[email protected]联系。

      键凯科技提供大批量生产产品及GMP级别产品,如需报价请与我们联系。

     

    1.  
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    109. Sousa, A., et al., Design of experiments to select triphenylphosphonium-polyplexes with suitable physicochemical properties for mitochondrial gene therapy, Journal of Molecular Liquids, 2020; 302.

    110. Chen, L., Ultra-small MoS2 nanodots-incorporated mesoporous silica nanospheres for pH-sensitive drug delivery and CT imaging, Journal of Materials Science & Technology, 2020.

    111. Amatya, R, et al., In Vitro and In Vivo Evaluation of PEGylated Starch-Coated Iron Oxide Nanoparticles for Enhanced Photothermal Cancer Therapy. Pharmaceutics. 2021, 13(6):871.

    112. Fu, D, et al., A novel redox-responsive ursolic acid polymeric prodrug delivery system for osteosarcoma therapy. Drug Delivery. 2021, 28(1):195-205.

    113. Gao, M, et al., A Manganese Phosphate Nanocluster Activates the cGAS‐STING Pathway for Enhanced Cancer Immunotherapy. Advanced Therapeutics. 2021, 2100065.

    114. Sheng, Q, et al., Comprehensively enhanced delivery cascade by transformable beaded nanofibrils for pancreatic cancer therapy. Nanoscale. 2021.

    115. Godinho, B.M., et al., PK Modifying Anchors Significantly Alter Clearance Kinetics, Tissue Distribution and Efficacy of Therapeutics siRNAs, Molecular Therapy-Nucleic Acids, 2022.

    116. Xu, K., et al., Injectable host-guest gel nanovaccine for cancer immunotherapy against melanoma. Materials Today Advances, 2022, 15.

    117. Fan, N., et al., Preparation of an HI-6-loaded brain-targeted liposomes based on the nasal delivery route and the evaluation of its reactivation of central toxic acetylcholinesterase, European Journal of Pharmaceutical Sciences, 184, 2023.

    118. Lin, Z., et al., Hypoxia-induced cysteine metabolism reprogramming is crucial for the tumorigenesis of colorectal cancer, Redox Biology, 2024. Keywords: Colorectal cancer; Cysteine/Cystine; Transporter genes; ATF4; Hypoxia; ROS homeostasis; methoxy PEG succinimidyl carboxymethyl ester of MW 5000 (PEG-5K)

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